Co-supervisor: Dr. Besides the reorganization of striped muscles, the cardiac muscle is also affected. The most common cardiac manifestations are consuction and other heart rhythm disturbances, which are caused cukorbetegség kezelésére osina the changes in the heart's pacemaker and conducive systems, due to muscle reorganization. In the course of our research we aim to investigate the role of invasive electrophysiological examination in the cardiologic risk evaluation in myotonic dystrophy.
Cardiologic risk evaluation in myotonic dystrophy - role of implantable loop recorder Co-supervisor: Dr. Comparison of conventionally performed and zero-fluoroscopic catheter ablation in AV nodal reentry tachycardias Supervisor: KUPÓ, Péter Zero-fluoroscopic ablation techniques reduce the harmful effects of ionizing radiation during electrophysiology procedures.
We aim to test the efficiency and safety of a zero-fluoroscopic strategy using 3D electroanatomic mapping system for diagnostics and radiofrequency ablation of AV nodal reentry tachycardias in a retrospective study. Comparison of conventionally performed and zero-fluoroscopic catheter ablation in paroxysmal supraventricular tachycardias Supervisor: KUPÓ, Péter Zero-fluoroscopic ablation techniques — have been able to use since september of in Pécs - reduce the harmful effects of ionizing radiation during electrophysiology procedures.
We aimed to test the efficiency and safety of a zero-fluoroscopic strategy using 3D electroanatomic mapping system for diagnostics and radiofrequency ablation of supraventricular tachycardias SVT in a retrospective study. Comparison of cryoballoon and ablation-index guided radiofrequency catheterablation in paroxysmal atrial fibrillation Supervisor: KUPÓ, Péter The number of transcatheter ablation procedures for atrial fibrillation grows year by year in Hungary.
During the procedure pulmonary vein isolation is performed. Lately the cryoballoon technique has become widespread available besides radiofrequency ablation. Moreover, contact force sensing catheters has been available in radiofrequency ablation.
In our research the procedures performed by these two different methods will be compared and analyzed. Comparison of intracardiac echocardiography-guided versus conventionally performed cavotricuspidal isthmus ablation in patients with atrial flutter Supervisor: KUPÓ, Péter Cavotricuspidal isthmus CTI is the target of the ablation for patients with atrial flutters.
These procedures are usually performed by only-fluoroscopy navigation. However, use of intracardiac echocardiography for CTI ablation has become type 2 diabetes and racing heart in recent years. In our study we aim to compare conventional, only fluoroscopy-guided vs ICE-guided CTI ablations in patients underwent invasive electrophysiologic procedures due to atrial flutters.
Comparison of procedural parameters of patients undergoing pulmonary vein isolation with conventional, steerable sheaths vs.
Conventionally, these procedures are performed with the use of steerable sheaths. Recently, steerable sheaths that can be visualized on 3D mapping system are available which can reduce the use of fluoroscopy during these procedures.
In our research the procedures performed by these two different tools will be compared and analyzed. Comparison of the effectiveness of cryoballoon and radiofrequecy catheterablation in persistent atrial fibrillation Co-supervisor: Dr. Lately the cryoballoon technique has became widespread available besides radiofrequency ablation.
In most cases the cause of sudden cardiac death is an occult cardiac disease. A lot of researches have already shown the differences between the phisiological sport heart and pathological cardiac conditions. In this study we examine sportsmen competing in different sport arts. Special ECG, particular echocardiographic examination furthermore spiroergometry are performing. The sportsmen with pathological results have a heart MRI examination, too. In the type 2 diabetes and racing heart situation, full revascularization plays an important role.
The different catheter based techniques are discussed, which are utilized during the diagnostic and interventional part in the catheter based revascularization. Due to the multiple associations of the vegetative nervous system, several factors affect HRV.
On one hand it means the wide range of applicability, however, on the other hand, results in low specificity. Accurate measurement requires special study-design, technical conditions and presentation. The topic covers both methodical and clinical investigations including cooperation with other specialties as well.
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Identification of novel biomarkers in acute myocardial infarction Supervisor: SZOKODI, István Acute coronary syndrome results mainly from rupture of an inflamed thin-capped plaque with secondary thrombus formation. Chemokines and cytokines have been suggested to orchestrate the inflammatory processes during atherogenesis, plaque destabilization, and infarct healing. We aim to identify novel biomarkers e. Investigation of 3-dimensional reconstruction of coronary angiography with computational fluid dynamics and its clinical significance Supervisor: BÁLINT, Alexandra Several methods are available for the diagnosis of coronary stenosis, of which the detection of the hemodynamic relevance is limited.
The most significant developmental need and tendency focus on are techniques that determine the fractional flow reserve FFR without the use of an invasive pressure measuring wire by calculating non-invasive virtual fractional flow reserve vFFR from a three-dimensional reconstruction of the coronary angiogram.
The three-dimensional 3D geometry of the coronary artery can be analyzed from the coronarography with 3D reconstruction software. Computational type 2 diabetes and racing heart dynamics CFD allows a comprehensive, in silico study of fluid properties after 3D reconstruction of vascular structures.
In addition to the existing study data, it can be assumed that CFD examination of the coronary sections results in the detection of flow parameters that are important for plaque progression.
Modern echocardiographic techniques and biomarkers in the diagnosis of heart failure Supervisor: FALUDI, Réka In addition to the classical, widespreadly used echocardiographic methods more new, special techniques tissue Doppler imaging, strain, strain rate have been developed. Systolic or diastolic functions of both the left and right ventricles as well as the atria are investigated by applying these new techniques in some special diseases systemic sclerosis, COPD, restrictive cardiomyopathy, etc.
In addition to the echocardiographic methods, serum levels of some biomarkers e. These factors can activate specific signaling pathways, such as mitogen-activated protein kinases MAPKs and calcineurin, which leads to increased expression of certain genes characteristic of cardiac hypertrophy, the so-called fetal gene program. Transcription factors play crucial role in integrating these cytosolic signaling cascades. Our studies may pave the way for the development of novel strategies in combating adverse remodeling and heart failure.
Our aim is to investigate if there is any sign of myocardial or vascular dysfunction even type 2 diabetes and racing heart the diagnosis of gestational diabetes. Echocardiography is performed to examine the systolic and diastolic function of the heart.
An easy-to-perform oscillometric method Arteriograph will be used to measure arterial stiffness parameters. Non-coding RNAs in pathological cardiac remodeling Supervisor: SZOKODI, István The development of cardiac remodeling is associated with fundamental changes in the molecular programs of the heart including the reactivation of fetal gene programs, deregulation of neurohormonal systems as well as the activation of senescence and various forms of cell death.
It has long been considered that these gene programs are primarily under the control of protein-based regulatory systems i.
Understanding the functional significance of these non-coding RNA transcripts in versatile cellular processes is the subject of intense investigation. According to the most recent estimates, the human genome encodes for ~ different microRNAs and ~ long non-coding RNAs.
Our main goal is to identify novel cell-type and context-specific interactions between, microRNAs, long non-coding RNAs, and mRNAs in regulating cardiac remodeling using the combination of in silico predictions, in vitro cell culture experiments, and animal models.
Non-invasive measurement of arterial stiffness parameters in assessment of cardiovascular risk Supervisor: GASZNER, Balázs Large amount of evidence is now available on the crucial role of preclinical organ damage in determining the cardiovascular risk of individuals.
Arterial stiffness parameters are commonly used for this purpose, to identify structural and functional changes of the arteries in the development of atherosclerotic disease. However, measuring arterial stiffness parameters is currently not sufficiently widespread, and thus the information it provides remains desirable but difficult to obtain. Novel developments offer different non-invasive, user friendly examination methods, which could solve this controversy.
The aim of our study is overcome these limitations and compare recently validated, time-saving, low expense systems: the carotid Doppler echo-tracking system and the oscillometric equipment with the carciac CT and MRI methods. Objective methods in cathlab pressure wire, IVUS, OCT Supervisor: HORVÁTH, Iván Gábor During coronarography the identification and characterization of stenosis are important, however there are only indirect information about the histopathological characteristics of type 2 diabetes and racing heart lesions, and the severity of the ischemia could not be judged properly in some cases.
The latter could be characterized by the utilization of pressure wire measurements, especially via the fractional flow reserve FFR. Peptidergic regulation of myocardial contractility Supervisor: SZOKODI, István Congestive heart failure is a major cause of morbidity and cukorbetegség kezelése berlinben despite recent advances in medical therapy.
The most commonly used positive inotropes acting via the cAMP—protein kinase A pathway, beta-adrenergic agonists and phosphodiesterase inhibitors, provide rapid and dramatic improvements in cardiac performance, producing immediate relief of heart failure symptoms; however, the prolonged use of these agents may lead to serious adverse cardiac effects.
Внезапно оно, видимо, осознало, что совершает ошибку. Пульсирующая мембрана уменьшилась в размерах, а издаваемые ею звуки поднялись в тоне на несколько октав, пока не улеглись в звуковой спектр нормальной человеческой речи.
We aim to study the functional significance of myocardium-derived secreted peptides, the so-called cardiokines, in the regulation of cardiac contractility. The characterized cardiokines and their signaling pathways may offer an attractive approach for treating patients with heart failure.
In Europe, every sixth male and seventh female cause of death is myocardial type 2 diabetes and racing heart. PCI has proven to be a reliable semi-invasive procedure for these disorders, but high age and its often associated comorbidities may limit its benefit. Earlier studies demonstrated lower success rates and the frequent complications following intervention among elderly.
The statistical method of meta-analysis is suitable for summing up the published studies in the subject, which also allows to analyzis of the of the obtained evidences and results. Procedural and epidemiological aspects of the interventional treatment of the acute myocardial infarction Supervisor: KOMÓCSI, András In the treatment of the acute myocardial infarction, interventional revascularization through coronary intervention has become of predominant importance.
A national network of catheter labs was established to provide early revascularization. Clinical characteristics of patients undergoing treatment for an event of myocardial infarction are recorded by the Hungarian Myocardial Infarction Register.
Our goal is to conduct observational clinical studies with the use of register data in order to identify factors influencing the prognosis of myocardial infarct patients. Prognostic significance of pulmonary hemodynamics paramaters in pulmonary arterial hypertension Supervisor: PORPÁCZY, Adél Pulmonary hypertension is a condition with heterogenous origin and poor prognosis.
The diagnosis and identification of the etiology frequently requires right heart catheterization. During the RHC several parameters of pulmonary circulation is determined. The aim of the project is to clarify prognostic significance of these parameters using clinical follow-up studies. Role of apelin in the regulation of myocardial contractility Supervisor: SZOKODI, István Congestive heart failure is a major cause of morbidity and mortality despite recent advances in medical therapy.
A cukorbetegség kezelése tojással, we have shown that apelin, a peptide secreted from the myocardium, is one of the most potent endogenous stimulators of cardiac contractility.
We aim to characterize the signaling mechanisms underlying the positive inotropic effect of apelin. The newly identified signaling pathways may represent attractive possible targets in the treatment of heart failure. Role of endothelin-1 in the regulation of myocardial contractility Supervisor: SZOKODI, István Congestive heart failure is a major cause of morbidity and mortality despite recent advances in medical therapy. Endothelin-1, a peptide secreted from the myocardium, is one of the most potent endogenous stimulators of cardiac contractility.
We aim to characterize the signaling mechanisms underlying the positive inotropic effect of type 2 diabetes and racing heart However, emerging evidence suggests a role for ROS in regulating various physiological cellular processes in the myocardium.
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We aim to characterize the signaling network activated by ROS in the regulation of cardiac contractility under physiological conditions. Systematic review and meta-analysis of outcomes after coronary revascularization procedures Supervisor: VOROBCSUK, András Meta-analysis is a statistical technique for summarising, and reviewing previously published quantitative research.
Practioners, clinicians have to face an informational boom of the modern medicine. There is too much information around for people to keep up to date, on the other hand high quality information is often not easy to find.
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Elaborating a summary of available literature and performing a critical review of the obtained data is becoming more and more important. Using meta-analysis, a specially developed statistical armamentarium that allows cumulating the available data of independent observation, enables to analyse a wide variety of questions and allows not only a summary but also an integration of the evidences with higher statistical power and more precise effect estimates.
Based on the results of the animal experiments of the last decades we assumed that PACAP might have a protective effect against ischemic injury due to its antiapoptotic effect.
Moreover, several studies have already proven that there may be a significant correlation between PACAP and the severity of heart failure; furthermore as an antiapoptotic polypeptide, it can influence the progression of heart failure. Based on all of these results we examine cardiac disorders with the etiology of ischemia such as acute myocardial infarct, ischemic heart disease and heart failure, furthermore we are going to detect the changes of serum PACAP levels due to the different therapies.
With these researches there will be known more details about the exact role of PACAP in the pathomechanism and progression of several cardiac diseases, so it might be a potential biomarker in the future.
For the definition of risk groups and the clinical management, it is of essential importance to characterize the properties that predispose to OHCA and negatively influence the clinical outcome. Patients who were treated with and without OHCA after a myocardial infarction MI in the years and who underwent coronary angiography are analyzed.
The role of the postprocedural cardiac MRI after cryoablation for atrial fibrillation.