About sharing Image source, Thinkstock A "worryingly high" number of children with type 1 diabetes have warning signs of long-term health complications, including blindness, a report says.
Modeling long-term diabetes and related complications in rats J Pharmacol Toxicol Methods. Mar-Apr ; Epub Nov Gyömrői út Electronic address: erika.
DOI: The aims of this study were to establish a model of long-term diabetes with sustained medium scale hyperglycemia and characterize the pathological changes detectable after 4months, with particular respect to dependence on the degree of hyperglycemia. Methods: Streptozotocin-induced diabetic CFY rats were subjected to four different insulin substitution protocols to achieve different levels of glycemic control Diabetic groups.
Dohányzás után, A cukorbetegség a második leggyakrabban előforduló szívbetegség oka
Eyes were investigated by ophthalmoscopy, kidney function by urine analysis, and neuropathy by functional tests. Retinal and renal morphological evaluations were performed by histology, immuno-histochemistry and electron microscopy.
Discussion: We established a treatment protocol in rats enabling complex investigation of diabetic retinopathy, nephropathy and neuropathy on a long-term period. Clearly hyperglycemic dependent parameters of these complications serve as good outcome measures for preclinical trials. Our results provide a useful basis for designing studies for testing preventative treatments as well as other translational medical research in this field.
Keywords: Anterior segment neovascularization; Chronic model; Cold allodynia; Diabetic nephropathy; Diabetic neuropathy; Diabetic a diabetes a diabetes Drug development; Insulin implant; Preclinical model; Streptozotocin. Copyright © Elsevier Inc. All rights reserved.
Type 2 Diabetes Signs \u0026 Symptoms (\u0026 Why They Occur) \u0026 Associated Conditions